Synergistic Effect of ZnO Nanoparticles and Carbon Nanotube and Polymeric Film on Electrochemical Oxidation of Acyclovir

A simple and selective carbon paste electrode has been developed for the electrochemicaldetermination of acyclovir (ACV). This electrode was designed by incorporation of multiwalledcarbon nanotubes (MWCNTs) and ZnO nanoparticles into the carbon paste matrix,and then poly (o-aminophenol; OAP) film were subsequently electropolymerized on it. Thesurface structure of nanoparticles were characterized by scanning electron microscopy (SEM)and transmission electron microscopy (TEM). Surface morphology and electrochemicalproperties of the prepared nanocomposite modified electrode were investigated by SEM andcyclic voltammetry (CV). The calibration graph was linear over the concentration range 0.089to 7.96 μg mL-1 for ACV determination with a detection limit of 0.067 μg mL-1. The proposedelectrode was successfully applied for ACV determination in pharmaceutical formulations withsatisfactory results.